ORAL BIO ROUTE & ONSET DURATION DOSE AVAILABILITY FORM
| ORAL BIO AVAILABILITY | ROUTE & FORM | ONSET | DURATION | DOSE |
GTN (NITROGLYCERIN)
All formulations are available for GTN FULLY nitrated polyol
| Poor | S/L (Tab/spray) | <5min | <1Hr | S/L : 0.3 – 0.6Mg Max up to 1.5Mg Spray : 400MCG as needed. |
| Patch(Chest area/Upper arm) | 30 – 60 Min | Prolonged | 20MCG -800MCG /Hr | |
| Infusion | <10Min | Determined by length of infusion | 5 -200MCG/Min |
ISOSORBIDE DINITRATE
| 20 -25% | ORAL TAB | 15 -40 MIN | 4-6HOURS | 5 -80Mg bd to TID |
| S/L TAB | <10MIN | 1-2 HOURS | 2.5Mg -10 Mg every 2-3Hours |
ISOSORBIDE MONONITRATE
| 100 % | CR Tab(Do not Crush) | 1 – 2 Hours | Prolonged > 12 Hours | 10 – 40Mg Daily |
